Dev Kumar Bhalse and R.K. Maheshwari Formulation Of Dual Release Dosage Form By Mixed Solvency Concept

Dev Kumar Bhalse and R.K. Maheshwari Formulation Of Dual Release Dosage Form By Mixed Solvency Concept

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Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) It is indicated for moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis, osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis. The main objective of present study was to explore mixed solvency concept in preparation of dual release tablet dosage form of indomethacin. The objective of the present research work is to develop once a day dual release tablet dosage form of the drug, to overcome gastric irritation caused by repeated use of NSAID in short duration of time. The immediate release is rapidly absorbed from the stomach to... The aim is to make water a strong solvent for the indomethacin for preparation of solid dispersion of drug using mixed solvency concept by use of safe solubilizers (niaicnamide, sodium benzoate and sodium citrate) and preclude the use of toxic organic solvents used in solvent evaporation technique.

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